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外周血微核试验是检测染色体损伤和快速筛选环境化学物致突变的常用遗传毒理学方法,其中胞质分裂阻滞微核试验(cytokinesis-block micronucleus assay,CBMN)是应用最广泛的检测外周血微核率的方法,后者已经作为生物标志广泛应用到染色体损伤和基因稳定性的研究中。为更好地促进CB微核在职业和环境毒物接触人群健康监护中的研究和应用,对CB微核的形成机制、结局、影响因素和优缺点及其研究进展做了综述。
Peripheral blood micronucleus test is a common genotoxic approach to detect chromosomal damage and rapid screening for mutagenicity of environmental chemicals. The cytokinesis-block micronucleus assay (CBMN) is the most widely used method for the detection of peripheral blood Micronucleus rate method, which has been widely used as a biomarker in the study of chromosome damage and gene stability. In order to promote the research and application of CB micronucleus in the health monitoring of occupational and environmental toxicants better, the formation mechanisms, outcomes, influencing factors, advantages and disadvantages of CB micronuclei and their research progress are reviewed.