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目的观察四妙散配合艾瑞昔布治疗急性痛风性关节炎的临床效果。方法将62例急性痛风性关节炎患者随机分为观察组和对照组各31例。观察组予四妙散配合艾瑞昔布片治疗,对照组予秋水仙碱组治疗,观察2组患者临床疗效、治疗前后临床症状改善程度、血尿酸水平、红细胞沉降率变化及不良反应。结果观察组总有效率为87.1%高于对照组的83.9%,但差异无统计学意义(P>0.05)。2组治疗后关节疼痛、肿胀、活动功能评分均优于治疗前(P<0.05),但2组治疗后比较差异无统计学意义(P>0.05)。观察组治疗后血尿酸、红细胞沉降率水平均低于治疗前及对照组,差异均有统计学意义(P<0.05,P<0.01);对照组治疗前后尿酸、红细胞沉降率比较差异无统计学意义(P>0.05)。结论四妙散配合艾瑞昔布不仅可明显改善急性痛风性关节炎症状,而且可降低血尿酸水平,值得临床上广泛使用。
Objective To observe the clinical effect of Simiao Powder combined with Aroclor in the treatment of acute gouty arthritis. Methods Sixty-two patients with acute gouty arthritis were randomly divided into observation group and control group with 31 cases each. The observation group was treated with Si Miao San with irisoxaban and the control group with colchicine. The clinical curative effect, the improvement of clinical symptoms before and after treatment, the level of serum uric acid, the change of erythrocyte sedimentation rate and the adverse reaction were observed. Results The total effective rate in the observation group was 87.1% higher than 83.9% in the control group, but the difference was not statistically significant (P> 0.05). The scores of joint pain, swelling and activity in the two groups were better than those before treatment (P <0.05), but there was no significant difference between the two groups after treatment (P> 0.05). The levels of serum uric acid and erythrocyte sedimentation rate in the observation group after treatment were lower than those before treatment and in the control group (P <0.05, P <0.01). There was no significant difference in the sedimentation rate of uric acid and erythrocyte between the two groups before and after treatment Significance (P> 0.05). Conclusion Si Miao San with irocoxib not only can significantly improve the symptoms of acute gouty arthritis, but also reduce the level of serum uric acid, it is widely used clinically.