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目的探讨血清降钙素原(PCT)对鉴别诊断社区获得性肺炎与肺结核的临床意义。方法收集2012年7月—2014年11月湖南省中医药研究院附属医院同期入院诊断为社区获得性肺炎患者(肺炎组)40例及肺结核患者(结核组)42例的血清标本,并以50例门诊健康体检者血清作为对照组。分析比较各组患者的血清降钙素原水平。结果肺炎组血清PCT>0.5 ng/m L的阳性病例共31例,明显高于结核组(P<0.05);肺炎组的测定结果主要分布在阳性组(PCT>0.5 ng/m L),阳性例数较其他两组显著升高(P<0.05);肺炎组PCT、CRP、WBC明显高于其他两组(P<0.05);肺炎组患者PCT水平与CURB-65评分呈现正相关的关系(r=0.95)。结论血清降钙素原的测定对鉴别诊断社区获得性肺炎和肺结核具有重要的临床意义。
Objective To investigate the clinical significance of serum procalcitonin (PCT) in the differential diagnosis of community-acquired pneumonia and pulmonary tuberculosis. Methods Serum samples of 40 patients diagnosed as community-acquired pneumonia (pneumonia group) and 42 pulmonary tuberculosis patients (tuberculosis group) were collected from the Affiliated Hospital of Hunan Academy of Traditional Chinese Medicine from July 2012 to November 2014, Cases of health examination of patients with serum as a control group. Analysis and comparison of serum procalcitonin levels in each group. Results There were 31 cases of positive cases of PCT> 0.5 ng / m L in pneumonia group, which were significantly higher than those of tuberculosis group (P <0.05). The results of pneumonia group were mainly positive (PCT> 0.5 ng / m L) The number of PCT, CRP and WBC in pneumonia group were significantly higher than those in the other two groups (P <0.05); PCT level in pneumonia group was positively correlated with CURB-65 score (P <0.05) r = 0.95). Conclusion The determination of serum procalcitonin has important clinical significance in differential diagnosis of community-acquired pneumonia and pulmonary tuberculosis.