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目的为了研究厦门地区男性低生育能力患者年龄和精子DNA完整性之间的关系。方法 353例男性不育患者分为40岁(含40岁)以上组和40岁以下组,患者的精子采用染色质扩散的方法进行精子DNA碎片分析。结果 40岁(含40岁)以上组的精子DNA碎片率的检出值明显高于40岁以下组(DNA碎片指数分别是27.83±2.06 and 24.81±6.77%,P<0.05)结论厦门地区男性低生育能力的患者的年龄对精子DNA完整性有极大的影响。
Objective To study the relationship between age and sperm DNA integrity in male patients with low fertility in Xiamen. Methods 353 male infertility patients were divided into 40-year-old group (above 40 years old) and 40-year-old group. The sperm of the patients were analyzed by chromatin diffusion method. Results The detection rate of sperm DNA fragmentation in the 40-year-old group was significantly higher than that of the 40-year-old group (DNA fragmentation index was 27.83 ± 2.06 and 24.81 ± 6.77%, respectively, P <0.05) The age of fertility patients has a great influence on sperm DNA integrity.