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目的分析单纯性肥胖儿童血清瘦素水平,探讨儿童肥胖发病机制。方法单纯性肥胖儿童33例,正常对照组43例,两组儿童均测标准身高、体重、计算体重指数(BMI),采用放射免疫分析法检测血清瘦索(leptin)水平。结果肥胖组儿童血清瘦素水平及BMI均值明显升高,与正常对照组间差异有显著性(P＜0．05)。结论单纯性肥胖儿童存在高瘦素血症,亦存在瘦素抵抗现象。
Objective To analyze the serum levels of leptin in simple obesity children and to explore the pathogenesis of childhood obesity. Methods 33 cases of simple obesity children, 43 cases of normal control group, two groups of children were measured standard height and weight, body mass index (BMI), radioimmunoassay was used to detect serum leptin levels. Results Serum leptin level and BMI in obese group were significantly higher than those in normal control group (P <0.05). Conclusion There is hyperlipidemia in simple obese children, and there is also the phenomenon of leptin resistance.