自2000年以来,手性有机胺化合物通过烯胺或亚胺盐机制,分别在羰基化合物的α-或β-位构建手性中心获得了很大的成功,并已成为不对称合成领域的常规方法。但近年来的研究发现上述反应机制可以通过共轭双键传递,发展了新颖的二烯胺、三烯胺以及插烯亚胺盐等新催化模式,实现了羰基化合物远端γ-、δ-甚至ε-位的活化,在多种不对称反应中实现了很好的立体控制,从而高效构建复杂的多官能团手性化合物。 Since 2000, chiral organic amine compounds have achieved great success through the enamine or imine salt mechanism, building chiral centers at the α- or β-positions of the carbonyl compounds, respectively, and have become routine in the field of asymmetric synthesis method. In recent years, however, it has been found that the above reaction mechanism can be transferred through conjugate double bonds to develop novel catalytic modes such as novel dienamines, trienamines, Even ε-site activation, in a variety of asymmetric reactions to achieve a good three-dimensional control, which efficiently build complex multi-functional chiral compounds.