【摘 要】
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Immunotherapy is a rapidly developing area of cancer treatment due to its higher specificity and potential for greater efficacy than traditional therapies.Immune cell modulation through the admin-istration of drugs,proteins,and cells can enhance antitumor
【机 构】
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Department of Chemical & Biological Engineering,University of Colorado,Boulder,CO 80303,USA
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Immunotherapy is a rapidly developing area of cancer treatment due to its higher specificity and potential for greater efficacy than traditional therapies.Immune cell modulation through the admin-istration of drugs,proteins,and cells can enhance antitumoral responses through pathways that may be otherwise inhibited in the presence of immunosuppressive tumors.Magnetic systems offer several advan-tages for improving the performance of immunotherapies,including increased spatiotemporal control over transport,release,and dosing of immunomodulatory drugs within the body,resulting in reduced off-target effects and improved efficacy.Compared to alternative methods for stimulating drug release such as light and pH,magnetic systems enable several distinct methods for programming immune re-sponses.First,we discuss how magnetic hyperthermia can stimulate immune cells and trigger thermore-sponsive drug release.Second,we summarize how magnetically targeted delivery of drug carriers can increase the accumulation of drugs in target sites.Third,we review how biomaterials can undergo magnetically driven structural changes to enable remote release of encapsulated drugs.Fourth,we describe the use of magnetic particles for targeted interactions with cellular receptors for promoting anti-tumor activity.Finally,we discuss translational considerations of these systems,such as toxicity,clinical compatibility,and future opportunities for improving cancer treatment.
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