论文部分内容阅读
目的探讨合并或不合并糖尿病的壮族高血压患者胰岛素抵抗(IR)和胰岛素敏感性状况,为壮族高血压的治疗提供参考材料。方法选取符合入选标准的130例壮族原发性高血压(EH)患者,分为合并糖尿病组与不合并糖尿病组,以健康者为对照,各组均分别进行口服葡萄糖耐量试验(OGTT),以公式法计算IR和胰岛素敏感性指数(ISI),分析合并或不合并糖尿病的壮族EH患者IR和ISI情况。结果不合并糖尿病的壮族EH患者餐后2h血糖(2hPG),空腹胰岛素(FINS)和胰岛素抵抗指数(HOMA-IR)高于正常水平,ISI低于正常水平(P<0.05);合并了临床糖尿病的壮族EH患者空腹血糖、2hPG、FINS、餐后2h胰岛素(PINS)和HOMA-IR均显著高于正常水平,ISI显著低于正常水平,与不合并临床糖尿病的壮族EH患者比较也有显著差异(P<0.05)。结论没有合并临床糖尿病的壮族EH患者已经存在有糖代谢受损、IR和胰岛素敏感性下降,合并临床糖尿病的壮族EH患者存在更加严重的糖代谢受损、IR和胰岛素敏感性下降。
Objective To investigate the status of insulin resistance (IR) and insulin sensitivity in Zhuang hypertension patients with and without diabetes mellitus, and provide reference materials for the treatment of hypertension in Zhuang people. Methods A total of 130 Zhuang patients with essential hypertension (EH) were enrolled in this study. The patients were divided into two groups: diabetic group and non-diabetic group. OGTT was used in each group as control IR and insulin sensitivity index (ISI) were calculated by the formula method, and the IR and ISI of Zhuang EH patients with or without diabetes mellitus were analyzed. Results The 2h postprandial plasma glucose (2hPG), fasting insulin (FINS) and insulin resistance index (HOMA-IR) in patients with EH without diabetes mellitus were higher than normal and ISI was lower than normal (P <0.05) Fasting blood glucose, 2hPG, FINS, postprandial 2h insulin (PINS) and HOMA-IR of Zhuang EH patients were significantly higher than the normal level, and ISI was significantly lower than the normal level, which was also significantly different from that of Zhuang EH without clinical diabetes mellitus P <0.05). Conclusion EH patients without clinical diabetes mellitus have impaired glucose metabolism, decreased IR and insulin sensitivity. Patients with Zhuang EH complicated with clinical diabetes have more severe impaired glucose metabolism and decreased IR and insulin sensitivity.