细胞的代谢重组在肿瘤细胞生长过程中起着重要作用。传统的观点认为,磷酸烯醇式丙酮酸羧化酶(PEPCK)在糖异生中起着关键作用,PEPCK能将三羧酸循环中的草酰乙酸转换成糖酵解通路中的磷酸烯醇式丙酮酸,随后在多种酶的作用下最终转换成葡萄糖。然而最近的研究发现,肠道上皮的PEPCK对糖异生的作用并不明显,PEPCK可能是三羧酸循环中的一个 Metabolic recombination of cells plays an important role in the growth of tumor cells. The traditional view is that phosphoenolpyruvate carboxylase (PEPCK) plays a key role in gluconeogenesis and that PEPCK converts oxaloacetate in the tricarboxylic acid cycle to phosphoenol in the glycolysis pathway Pyruvate, which is subsequently converted to glucose by various enzymes. However, recent studies have found that the effect of PEPCK on gluconeogenesis in the intestinal epithelium is not significant, and PEPCK may be one of the three carboxylic acid cycles