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目的观察卡托普利联合美托洛尔治疗慢性心力衰竭的临床疗效。方法将102例慢性心力衰竭患者随机分为观察组和对照组各51例。对照组给予常规内科综合治疗,观察组在对照组治疗基础上给予卡托普利联合美托洛尔治疗,比较2组患者心功能变化和8min步行距离。结果治疗前,2组患者的左室舒张末期内径、左室收缩末期内径和左室射血分数比较差异无统计学意义(P>0.05);治疗后,2组左室舒张末期内径、左室收缩末期内径降低,左室射血分数升高,且观察组变化程度大于对照组,差异均有统计学意义(P<0.05)。观察组的8min步行距离是(573.1±78.4)m长于对照组的(409.8±15.7)m,差异有统计学意义(P<0.05)。结论卡托普利联合美托洛尔治疗慢性心力衰竭临床疗效肯定,可明显改善患者心功能,并提高患者运动能力,值得推广应用。
Objective To observe the clinical efficacy of captopril combined with metoprolol in the treatment of chronic heart failure. Methods 102 cases of chronic heart failure were randomly divided into observation group and control group of 51 cases. The control group was given routine medical treatment. The observation group was treated with captopril combined with metoprolol on the basis of the control group. The changes of cardiac function and walking distance in 8 minutes were compared between the two groups. Results Before treatment, left ventricular end-diastolic dimension, left ventricular end-systolic diameter, and left ventricular ejection fraction were not significantly different between the two groups (P> 0.05). After treatment, the left ventricular end-diastolic diameter The end systolic diameter decreased, the left ventricular ejection fraction increased, and the degree of change in the observation group was greater than that in the control group, with statistical significance (P <0.05). The walking distance of observation group was (573.1 ± 78.4) m longer than that of control group (409.8 ± 15.7) m, the difference was statistically significant (P <0.05). Conclusion Captopril combined with metoprolol in the treatment of chronic heart failure clinical curative effect is positive, can significantly improve patient’s cardiac function and improve patient’s exercise capacity, it is worth to promote the application.