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对人体上呼吸道分泌物中的头孢噻肟(CTX)及其活性代谢产物去乙酰头孢噻肟(DCTX)进行定量分析,以显示药物在肺部分泌液的浓度与血浓度的关系.17例病人中12例为男性,年龄26～78岁.静脉滴注头孢噻肟2g,5～10分滴完,每6小时一次.痰标本于给药4次后1～2小时以X-射线证实异常的对侧支气管分节通过气管镜吸出,同时抽取血标本,离心后,血清保存于-70℃,待测.
The quantitative analysis of cefotaxime (CTX) and its active metabolite cefotaxime (DCTX) in human upper respiratory secretions showed the relationship between the concentration of the drug in the lungs and the blood concentration, and 17 patients 12 cases were male, aged 26 to 78. Intravenous cefotaxime 2g, 5 to 10 minutes end, once every 6 hours.Sputum specimens after administration of 4 times 1 to 2 hours confirmed by X-ray abnormalities The contralateral bronchial section was aspirated through a bronchoscope and blood samples were taken at the same time. After centrifugation, the serum was stored at -70 ° C and tested.