机体糖、脂及蛋白质代谢异常导致的糖尿病、肥胖和高血压是子宫内膜癌发病的高危因素,代谢紊乱性疾病发生发展的各个环节与子宫内膜癌的发病机制密切相关,两者存在共同的激素水平异常及代谢酶类和细胞因子的表达异常。其中,糖代谢异常的可能致病基础胰岛素抵抗导致多种肿瘤的发生发展,其与子宫内膜癌发病的关系也日益受到重视。通过改善机体糖代谢状况,治疗糖尿病以及控制体质量等提高内膜癌治愈率,成为指导预防及治疗内膜癌的有效手段。 Diabetes mellitus, obesity and hypertension caused by the abnormal metabolism of sugar, fat and protein are the risk factors of endometrial cancer. The development and progression of metabolic disorders are closely related to the pathogenesis of endometrial cancer, both of which are common Abnormal hormone levels and metabolic enzymes and cytokine abnormalities. Among them, the abnormal glucose metabolism may lead to underlying disease caused by a variety of oncology insulin resistance and its relationship with the incidence of endometrial cancer is also increasingly valued. By improving the body’s glucose metabolism, the treatment of diabetes and control the body weight to improve the cure rate of endometrial cancer has become an effective means of prevention and treatment of endometrial cancer.