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信使RNA(message RNA,mRNA)降解在调控哺乳动物基因表达中起着关键作用,其功能失调促进多种与炎症和恶性肿瘤相关基因的过量表达[1]。研究发现,多种炎症和恶性肿瘤相关基因mRNA的3′非翻译区(3′untranslated region,3′UTR)含有保守的AU重复序列(AU-rich element,ARE),该序列与RNA结合蛋白相互作用共同调节mRNA的稳定性[2]。Tristetraprolin(TTP)是由锌指
Degradation of message RNA (mRNA) plays a key role in the regulation of mammalian gene expression, and its dysfunction promotes the overexpression of a variety of genes associated with inflammation and malignancy [1]. It has been found that the 3’untranslated region (3’UTR) of various inflammatory and malignant tumor related genes contains a conserved AU-rich element (ARE) which interacts with the RNA-binding protein The role of common regulation of mRNA stability [2]. Tristetraprolin (TTP) is made from zinc finger