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慢性阻塞性肺病的早期诊断比较困难,即使应用较敏感的肺功能检查,如第1秒时间肺活量(FEV1.0)、最大呼气中期流速(MMEF),有时也不能反映早期小气道疾患。闭合容量(Closing Capacity简称CC)测定即是早期诊断小气道疾患的一种简单而敏感的方法。本文对CC综述如下。 1949年已发现在残气(RV)位吸入纯氧后再缓慢而匀速呼气时,呼气终末的氮浓度上升。1967年首次提出闭合气量(Closing Vo-
Early diagnosis of chronic obstructive pulmonary disease is more difficult, even if the application of more sensitive pulmonary function tests, such as the first second time vital capacity (FEV1.0), the maximum expiratory flow rate (MMEF), and sometimes can not reflect early small airway disease. Closure capacity (Closing Capacity referred to as CC) determination is an early diagnosis of small airway disease, a simple and sensitive method. This article reviews CC as follows. In 1949, it was found that at the end of exhalation, the concentration of nitrogen was increased when breathing slowly and at a constant rate after inhaling pure oxygen at the residual (RV) level. First proposed in 1967 closed volume (Closing Vo-