临床使用可卡因已近百年,但对它在人体内的代谢和毒性却知道甚少。在人体上作可卡因半数致死量的实验尚未见有报导。少数报导局部应用可卡因的“最大安全量”为200毫克,Adriani和 Zepernick 根据临床经验报告“局部限量” Clonocaine has been used clinically for nearly a century, but little is known about its metabolism and toxicity in the human body. There has been no report on the lethal dose of cocaine in the human body. A few reported a “maximum safe dose” of 200 mg for topical cocaine use and Adriani and Zepernick reported “localized limits” based on clinical experience