人体正常血糖濃度,按葡萄糖計算,每100毫升血液为80—180毫克。假如体內因某种关系,代謝机能發生故障,血糖濃度就会失去平衡,超出范圍,产生所謂糖尿病症狀,糖从尿內大量排出。过去一般均用胰島素作治疗剂。胰島素很快为胃腸中的蛋白水解酶所破坏,不能口服,必須注射給药,很不方便,久为病人所苦。因此适于口服的胰島素代用品,在近代医药上就受到特別重視。口服降血糖药,过去曾發現双胍十二烷(decamethylene diguanidine,Synthalin)有降低血糖作用,但毒性較大,对肝臟有伤害。Ferner曾用白鼠作試驗,証明它对胰臟Lang Normal human blood glucose concentration, calculated as glucose, 80-180 mg per 100 ml of blood. If the body due to some kind of relationship, metabolic failure, blood glucose concentration will be out of range, resulting in the so-called symptoms of diabetes, sugar excretion from the urine. In the past generally use insulin as a therapeutic agent. Insulin is quickly destroyed by proteolytic enzymes in the stomach and intestines, can not be taken orally, and must be administered by injection. It is inconvenient and painful for a long time. Therefore, insulin substitutes suitable for oral administration have received special attention in modern medicine. Oral hypoglycemic drugs, the past has been found that biguanide dodecane (decamethylene diguanidine, Synthalin) has a hypoglycemic effect, but the toxicity of the liver damage. Ferner used to experiment with white mice to prove that it has a positive effect on pancreas Lang