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目的测定 2型糖尿病患者的胰岛功能及红细胞胰岛素受体数目和亲和力。方法采用受体放射分析法测定健康对照组、2型糖尿病肥胖组、非肥胖组的红细胞胰岛素受体 ,用放射免疫法测定胰岛素水平。结果 2型糖尿病肥胖组红细胞胰岛素受体数目显著减少 ,非肥胖组与对照组比较无显著差异 ,3组的亲和常数无显著差异。 2型糖尿病肥胖组、非肥胖组的胰岛素峰值时间较对照组后延 ,且峰值水平显著减低 ,非肥胖组减低更加明显。结论 2型糖尿病患者存在胰岛 β细胞胰岛素分泌反应异常 ,非肥胖组胰岛功能损害更加明显。肥胖组红细胞胰岛素受体数目减少可能是其产生或加强胰岛素抵抗的原因之一。
Objective To determine the islet function and the number and affinity of erythrocyte insulin receptor in type 2 diabetic patients. Methods The receptor of erythrocyte insulin receptor was determined by radioimmunoassay in healthy control group, type 2 diabetic obesity group and non-obese group. The levels of insulin were measured by radioimmunoassay. Results The number of erythrocyte insulin receptor in obesity group was significantly decreased in type 2 diabetes mellitus group. There was no significant difference between non - obese group and control group, but there was no significant difference in affinity constant between 3 groups. Insulin peak time in type 2 diabetic obesity group and non-obese group was delayed than that in control group, and the peak level was significantly reduced. The decrease in non-obese group was more obvious. Conclusion Patients with type 2 diabetes have abnormal pancreatic β-cell insulin secretion, and islet dysfunction is more obvious in non-obese patients. Reduced number of erythrocyte insulin receptors in the obese group may be one of the reasons that they produce or enhance insulin resistance.