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Periostin又被称为成骨细胞特异性因子-2,最初从小鼠的成骨细胞系MC3T3-E1中分离[1]。Periostin作为细胞黏附蛋白能够促进成骨,此后其同源基因在人类及斑马鱼上也被克隆[2-3]。Periostin在骨外膜、软骨膜、牙周膜、肌肉筋膜、软骨关节面以及关节韧带中高表达。因此,Periostin被认为在形成和维持上述机械应力持续存在的组织中发挥了重要作用[4]。此外,也有研究证实了Periostin的表达与心脏的发育和心脏疾病密切相关[5-6]。最近,有许多研究报道了Periostin在多种人类恶性肿瘤的细胞系以及肿瘤实体中高表达。本文将Periostin在恶性肿瘤中的作用综述如下。
Periostin, also known as osteoblast-specific factor-2, was originally isolated from the mouse osteoblastic cell line MC3T3-E1 [1]. Periostin, as a cell adhesion protein, promotes osteogenesis, followed by its homologous genes also cloned in humans and zebrafish [2-3]. Periostin is highly expressed in the periosteum, perichondrium, periodontal ligament, muscle fascia, cartilage articular surface and articular ligaments. Therefore, Periostin is thought to play an important role in the formation and maintenance of the persistence of these mechanical stresses [4]. In addition, studies have also confirmed that Periostin expression is closely related to heart development and heart disease [5-6]. Recently, many studies have reported that Periostin is highly expressed in various human malignant tumor cell lines and tumor entities. The role of Periostin in malignant tumors is summarized below.