论文部分内容阅读
目的分析支原体肺炎患儿血清硒(Se)、一氧化氮(NO)水平与病情严重程度的关系。方法选择84例支原体肺炎患儿,其中急性期组48例,恢复期组36例,对照组40例健康儿童,检测3组血清Se、NO水平,同时测定免疫球蛋白Ig G、Ig A、Ig M含量的变化,采用《临床肺部感染评分表》对患儿病情严重程度进行评估,分析支原体肺炎患儿血清Se、NO水平、免疫球蛋白水平与病情严重程度的关系。结果 1对照组血Se水平高于恢复期组与急性期组(P<0.05),恢复期组血Se水平高于急性期组(P<0.05),对照组血NO水平低于恢复期组与急性期组(P<0.05),恢复期组NO水平低于急性期组(P<0.05);2对照组Ig G水平高于恢复期组与急性期组(P<0.05),其Ig M水平低于恢复期组与急性期组(P<0.05),恢复期组Ig M水平低于急性期组(P<0.05);3急性期重症组血Se水平低于轻症组,NO水平高于轻症者(P<0.05);急性期重症组Ig M水平高于轻症组(P<0.05),其Ig A、Ig G水平对比差异无统计学意义(P>0.05);4支原体肺炎病情严重程度与血Se水平呈负相关,与血NO呈正相关,与Ig M呈正相关。结论补充适量Se,阻断NO、Ig M过量分泌,可改善支原体肺炎患儿病情,对提升临床治疗效果有一定的促进作用。
Objective To analyze the relationship between selenium (Se), nitric oxide (NO) and the severity of mycoplasma pneumonia in children. Methods Eighty-four children with mycoplasmal pneumonia were selected, including 48 cases in acute phase, 36 cases in convalescence group and 40 healthy children in control group. Serum levels of Se and NO were measured in 3 groups. Ig G, Ig A, Ig M content of the changes, the use of “clinical pulmonary infection score” to assess the severity of the disease in children with Mycoplasma pneumonia in serum Se, NO levels, immunoglobulin levels and the severity of the relationship. Results The level of serum Se in the control group was higher than that in the recovery group and the acute phase group (P <0.05). The serum Se level in the recovery group was higher than that in the acute phase group (P <0.05) (P <0.05). The level of NO in convalescent group was lower than that in acute phase group (P <0.05). Ig G level in control group was higher than that in convalescent group and acute phase group (P <0.05) (P <0.05). IgM level in convalescent group was lower than that in acute group (P <0.05). Serum level of Se in acute severe group was lower than that in mild group and NO level was higher than that in acute group (P <0.05). The level of IgM in acute severe group was higher than that in mild group (P <0.05), while there was no significant difference in Ig A and Ig G levels between the two groups (P> 0.05). 4 Mycoplasma pneumonia Severity and serum Se level was negatively correlated with serum NO was positively correlated with IgM was positively correlated. Conclusion Selenium supplementation, blocking the excessive secretion of nitric oxide and IgM can improve the condition of children with mycoplasma pneumonia, which can promote the effect of clinical treatment.