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目的 :了解急性白血病 (AL)患儿血清中可溶性白细胞介素 2受体 (s IL- 2 R)和肿瘤坏死因子 α(TNFα)水平及其临床意义。方法 :采用 EL ISA及 RIA测定 2 7例急性淋巴细胞白血病 (AL L )和 31例急性非淋巴细胞白血病 (ANL L )及 2 0例健康儿童的血清 s IL - 2 R和 TNFα水平。结果 :AL患儿血清 s IL - 2 R和 TNFα发病期明显高于缓解期和正常儿童 ,后二者差异无统计学意义。发病期经化疗完全缓解后降至正常水平 ,化疗完全缓解和死亡患儿的化疗前血清 s IL- 2 R和 TNFα水平差异无统计学意义。结论 :AL 患儿发病期血清 s IL- 2 R和 TNFα对其诊断、病情监测和疗效判断有重要参考意义。
Objective: To investigate the serum levels of soluble interleukin 2 receptor (sIL-2R) and tumor necrosis factor α (TNFα) in children with acute leukemia (AL) and their clinical significance. Methods: The serum levels of IL - 2R and TNFα in 27 acute lymphoblastic leukemia (AL L) and 31 acute non - lymphocytic leukemia (ANL L) and 20 healthy children were measured by ELISA and RIA. Results: The serum levels of IL - 2R and TNFα in children with AL were significantly higher than those in children with remission and normal controls. There was no significant difference between the two groups. After the onset of chemotherapy was completely relieved to normal levels, complete remission and chemotherapy in children with chemotherapy before the serum levels of s IL-2 R and TNFα no significant difference. Conclusion: Serum levels of IL-2R and TNFα in children with AL have important reference value in diagnosis, disease monitoring and curative effect judgment.