绝大多数β-肾上腺素能受体阻滞剂具有β-激动剂异丙肾上腺素分子的基本骨架(Ⅰ),包括芳香核、β-羟基侧链及氨基三部份。根据萘心定和心得安的结构活性关系的资料,氮上无取代基的伯胺化合物有一定活性,用烷基特别是α-碳原子上有甲基的分叉烷基取代的仲胺,其活性显著增高,而氮上两个氢均被取代的叔胺活性又下降。目前用于临床的β-阻滞 The vast majority of beta-adrenergic blockers possess the basic backbone of the [beta] -agonist isoprenaline (I), including the aromatic nucleus, the beta-hydroxy side chain, and the three amino groups. Based on the information about the structural activity of propranolol and propranolol, primary amine compounds without nitrogen on the nitrogen have some activity, secondary amines substituted with alkyl groups, especially those having a methyl group on the α-carbon atom, Its activity was significantly increased, while the nitrogen on both hydrogen were replaced tertiary amine activity decreased. Currently used for clinical β-block