本研究观察５６例丙肝患者（急性２７例，慢性２９例）ＰＢＭＣ经ＰＨＡ刺激后的ｍＩＬ－２Ｒ表达和血清ｓＩＬ－２Ｒ水平，设健康对照组３０例。结果：⑴丙肝患者ｍＩＬ－２Ｒ表达较低，急、慢性之间差异无显著性；⑵丙肝患者血清ｓＩＬ－２Ｒ水平较高，急性组高于慢性组；⑶丙肝患者ｍＩＬ－２Ｒ表达和血清ｓＩＬ－２Ｒ水平之间无明显关系。表明ｍＩＬ－２Ｒ表达不足和ｓＩＬ－２Ｒ水平升高在丙肝患者机体免疫抑制机制中起重要作用；提示ｓＩＬ－２Ｒ可作为丙肝患者临床观察指标 This study was to observe the expression of mIL-2R and serum sIL-2R in 56 patients with acute hepatitis C (27 patients in acute and 29 chronic patients) stimulated by PHA. Thirty healthy controls were enrolled. Results: (1) The expression of mIL-2R was lower in patients with hepatitis C than those in patients with chronic hepatitis C (2) The levels of serum sIL-2R were higher in patients with hepatitis C than those in patients with chronic hepatitis C -2R level no significant relationship between. These results indicate that under-expression of mIL-2R and elevated sIL-2R play an important role in the mechanism of immunosuppression in hepatitis C patients. It is suggested that sIL-2R can be used as clinical observation index for hepatitis C patients