The multivariate information comprehensive processing technique is especially important at present to the digital mineral prospecting. However, the GIS-based weights of evidence have provided us with a powerful tool for the quantitative assessment of mineral resource potential. In this paper, the mineralization model is established, based on the achievements made by previous researchers, to mend such deficiencies as few references on ore fields in Yujiacun, Yunnan Province and the shortage of quantitative prediction and assessment of mineral resources. In addition, the weights of evidence are used to make a systematic quantitative prediction and assessment of mineral resources there, so that 2 mineral prospecting target areas of grade Ⅰand 8 mineral prospecting target areas of grade Ⅱ are delineated, providing the further mineral resource exploration with the basis for the selection of mineral deposits. The multivariate information comprehensive processing technique is especially important at present to the digital mineral prospecting. However, the GIS-based weights of evidence have provided us with a forcing tool for the quantitative assessment of mineral resource potential. In this paper, the mineralization model is established, based on the achievements made by previous researchers, to mend such deficiencies as few references on ore fields in Yujiacun, Yunnan Province and the shortage of quantitative prediction and assessment of mineral resources. In addition, the weights of evidence are used to make a systematic quantitative prediction and assessment of mineral resources there, so that 2 mineral prospecting target areas of grade I and 8 mineral prospecting target areas of grade II are delineated, providing the further mineral resource exploration with the basis for the selection of mineral deposits.