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随着极低体质量儿救治水平的提高,新生儿深部真菌感染已成为新生儿重症监护室中日益突出的问题。本文回顾性分析新生儿深部真菌感染的易感因素、高危因素,认为低胎龄儿、极低体质量、使用中心静脉导管、胃肠外营养、气管插管、以及长期应用抗生素特别是三代头孢菌素而致的肠道菌群失调等与新生儿深部真菌感染与有关。近年来,血清1-3-β-D葡聚糖含量用于早期诊断具有较好的灵敏度和特异性。治疗上尚没有一致的意见,不少学者提出预防性治疗的可行性。
With the improvement of the treatment of very low birth weight children, neonatal deep fungal infection has become an increasingly prominent problem in neonatal intensive care unit. This article retrospectively analyzed the neonatal risk factors for deep fungal infections, risk factors, that low-gestational age children, very low body weight, the use of central venous catheters, parenteral nutrition, endotracheal intubation, and long-term use of antibiotics, especially third-generation cephalosporins Mycotoxin-induced intestinal flora and other neonatal deep fungal infection. In recent years, serum 1-3- β-D glucan content for early diagnosis with good sensitivity and specificity. There is no consensus on the treatment, many scholars put forward the feasibility of preventive treatment.