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创伤应激后机体会发生儿茶酚胺、糖皮质激素、胰岛素、胰高血糖素、生长激素、C肽、瘦素等物质释放、生物活性以及相互作用等改变,从而影响机体的糖代谢,造成血糖升高。目前创伤应激后高血糖的处理手段包括胰岛素治疗、C肽、促肾上腺皮质激素释放因子受体拮抗剂、脂肪细胞激素和1,6-二磷酸果糖等的应用。本文就近年来关于上述问题的研究进行综述,着重阐明创伤应激后高血糖的神经内分泌调节机制与处理。
Post-traumatic stress occurs catecholamine, glucocorticoid, insulin, glucagon, growth hormone, C-peptide, leptin and other substances release, biological activity and interaction changes, thus affecting the body’s glucose metabolism, causing blood sugar rise high. The current treatment of post-traumatic stress hyperglycemia include insulin therapy, C-peptide, corticotropin releasing factor receptor antagonist, adipokines and fructose-1,6-diphosphate applications. This review summarizes the recent studies on the above problems and focuses on elucidating the mechanism and treatment of neuroendocrine regulation after hyperglycemia.