北京朝阳医院妇产科计划生育小组对服用复方18甲基炔诺酮长效口服避孕药一年以上的妇女,在1971年11月第一次检查的基础上,1972年9～11月进行第二次检查,共计180例。检查结果:仅有1例发现乳房有肿块,占0.55%,该例乳房肿块大小为一厘米直径,诊断为囊性乳腺癌,无癌可疑。进行子宫颈防癌刮片检查170例,均未发现癌细胞或核异质。药物对肝、脾、血压基本无影响,部分人服药后出现肝功能单项异常,但多无临床症状,且停 Beijing Chaoyang Hospital, Obstetrics and Gynecology family planning group taking compound 18 norgestrel long-term oral contraceptives more than one year of women, in November 1971 the first inspection based on the 1972 September to November The second examination, a total of 180 cases. Examination results: Only 1 case found a breast mass, accounting for 0.55%, the size of the breast mass was 1 cm in diameter, diagnosed as cystic breast cancer, no cancer suspicious. 170 cases of cervical anti-cancer smear examination, no cancer cells or nuclear all found. Drugs on the liver, spleen, blood pressure basically no effect, some people after taking a single abnormal liver function, but no clinical symptoms, and stop