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目的:应用动态心电图评价依帕司他对糖尿病患者心率变异性的影响,确认依帕司他治疗糖尿病心脏自主神经病变的疗效。方法:收集糖尿病合并心脏自主神经病变患者100例,分为治疗组和对照组,治疗组患者口服依帕司他50 mg,tid,共8周。运用24 h动态心电图检测所有患者在治疗前后心率变异性指标的变化,观察依帕司他治疗糖尿病心脏自主神经病变的疗效。结果:治疗组心率变异性各项指标治疗2个疗程后较治疗前有显著提高,自主神经症状明显好转,与对照组比较有显著意义。结论:依帕司他治疗糖尿病心脏自主神经病变的疗效显著,可改善患者心率变异性。
Objective: To evaluate the effect of epalrestat on heart rate variability in patients with diabetes mellitus by dynamic electrocardiogram and to confirm the efficacy of epalrestat in the treatment of diabetic autonomic neuropathy. Methods: One hundred patients with diabetes mellitus and cardiac autonomic neuropathy were collected and divided into treatment group and control group. The patients in treatment group were given eptazostigmine 50 mg, tid for 8 weeks. The 24 h ambulatory electrocardiogram was used to detect changes of heart rate variability in all patients before and after treatment, and the effect of epalrestat on diabetic autonomic neuropathy was observed. Results: The indexes of heart rate variability in treatment group were significantly improved after 2 courses of treatment compared with those before treatment, and the symptoms of autonomic nervous were obviously improved. Compared with the control group, the indexes of treatment group had significant significance. Conclusion: The efficacy of epalrestat in the treatment of diabetic autonomic neuropathy is significant, which can improve the heart rate variability.