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目的:观察毓麟珠治疗脾肾阳虚型卵巢早衰(POF)的临床疗效。方法:将56例卵巢早衰患者随机分成两组,治疗组28例,采用中药毓麟珠加西药克龄蒙治疗;对照组26例,只采用西药克龄蒙,3个月为1个疗程,两组均连续治疗2个疗程后停药观察1个疗程。主要观察两组的低刺激素症状改善情况及激素水平变化。结果:两组治疗后临床低雌激素证候群改善情况比较,治疗组优于对照组,两组比较有显著性差异(P<0.05);两组患者治疗后促卵泡生成素(FSH)和血清雌二醇(E2)与治疗前比较,均有极显著性差异(P<0.01),治疗后两组血清黄体生成素(LH)水平均明显下降,与治疗前比较,均有显著性差异(P<0.05);停药时治疗组和对照组总有效率分别为92.86%和88.46%,两组比较,有显著性差异(P<0105);停药后3个月治疗组和对照组总有效率分别为92.86%和76.92%,两组比较,有显著性差异(P<0.05)。结论:毓麟珠配合激素治疗可以改善脾肾阳虚型卵巢早衰患者症状,改善卵巢功能作用持久,疗效稳定,具有较强优势。
Objective: To observe the clinical efficacy of Yulin beads in treating spleen-yang deficiency type of premature ovarian failure (POF). Methods: 56 cases of premature ovarian failure were randomly divided into two groups, the treatment group 28 cases, the use of traditional Chinese medicine Yulin beads plus western medicine Kelin treatment; control group of 26 patients, only using Western medicine grams of age, three months for a course of treatment, Two groups were discontinued treatment after 2 courses of treatment observed a course of treatment. The main observation of two groups of hypothyroid hormone symptoms and hormone levels. Results: The improvement of clinical low estrogen syndrome in both groups after treatment was better than that of the control group (P <0.05). The levels of follicle-stimulating hormone (FSH) and follicle stimulating hormone Serum estradiol (E2) had a significant difference compared with those before treatment (P <0.01). After treatment, serum luteinizing hormone (LH) levels in both groups were significantly decreased compared with before treatment, there was a significant difference (P <0.05). The total effective rates of the treatment group and the control group were 92.86% and 88.46% respectively when the drug was withdrawn, there was significant difference between the two groups (P <0.05); the treatment group and the control group The total effective rates were 92.86% and 76.92%, respectively, with significant difference between the two groups (P <0.05). Conclusion: Yulin beads with hormone therapy can improve the symptoms of patients with spleen-yang deficiency type of premature ovarian failure, improve the long-term ovarian function, efficacy is stable, has a strong advantage.