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1984年我们报道了鼻咽癌病人全血硒含量显著地低于健康人。为了进一步探讨硒与鼻咽癌的关系,我们于1985～1986年测定了鼻咽癌高发区四会县鼻咽癌患者头发、血清及该地区大米饮水中硒的含量,并与鼻咽癌低发区五华县作比较。由于硒是人体中谷胱甘肽过氧化物酶(SeGSH—PX)的重要成份,该酶活性的高低在一定程度上可以作为衡量机体硒的生理生化功能。因此我们于1987年又作了鼻咽癌患者及健康人血中谷胱甘肽过氧化物酶的测定。
In 1984 we reported that selenium levels in whole blood of patients with NPC were significantly lower than those of healthy individuals. In order to further explore the relationship between selenium and nasopharyngeal carcinoma, we measured the content of selenium in the hair, serum and rice drinking water of patients with nasopharyngeal carcinoma in Sihe County, a high incidence area of nasopharyngeal carcinoma from 1985 to 1986, and compared with that of nasopharyngeal carcinoma Wuhua County hair area for comparison. Because selenium is an important component of glutathione peroxidase (SeGSH-PX) in the human body, the activity of this enzyme can be used as a measure of physiological and biochemical functions of selenium to a certain extent. Therefore, we made the determination of glutathione peroxidase in the blood of patients with nasopharyngeal carcinoma and healthy human in 1987.