老年性窦房结功能减退是指由窦房结功能异常所导致的各种心律失常。老年窦房结功能减退的发生机制目前仍不十分明确，有众多因素参与，microRNAs相关的窦房结细胞膜表面各种离子通道蛋白表达变化、缝隙连接蛋白表达变化、窦房结内及边缘的炎症反应、窦房结内细胞凋亡周期的改变可能参与了这一过程。现通过系统综述，归纳总结近年来关于microRNAs参与老年窦房结功能减退的研究进展。“,”Sinus node dysfunction is associated with aging.It presents clinically as a varied arrhythmia and is responsible for half of the pacemaker implantations every year.While the pathogenesis of sinus node dysfunction is still unclear, factors including the change of ex-pression of microRNAs-related ion channels, gap-junction in the membrane of the sinus node cell, inflammation around and within the sinus node, apoptosis, and the abnormality of the cell cycle of pacemaker cells may be contributors to the development of sinus node dysfunction. This review analyzes the recent research of roles of microRNAs in sinus node dysfunction.