Bioremediation is a process mediated by microorganisms, which is a sustainable and eco-friendly way to degrade and detoxify environmental contaminants. Soil microbiome clearly becomes a key component of bioremediation as it is more stable and efficient than pure culture, being recognized as one of the scientific frontier of soil environmental science and technology field. Recently, many progresses have been made in the investigation of remediation mechanisms by soil microbiomes and the interactions inside the microbiome. It greatly expanded our ability to characterize the remediating function of the soil microbiome and identify the factors that influence the efficiency of soil microbiome in remediation. Here, we suggest that soil microbiome is a promising strategy for soil remediation. The field is now poised to identify how we can manipulate and manage the soil microbiome to improve the remediation efficiency and increase soil fertility at the same time. Thereby, this review aimed to emphasize the importance of soil microbiome in bioremediation and promote further development of this strategy into a widely accepted technique.