论文部分内容阅读
目的研究癫癎患儿的免疫状态。方法采用单向琼脂扩散法测定癫癎患儿(癫癎组)、高热惊厥(FS)患儿(FS组)及健康儿童(健康对照组)血清免疫球蛋白和补体水平;采用直接免疫荧光法测定其血液T淋巴细胞(CD)比率。结果与FS组及健康对照组比较,癫癎组患儿血清IgG、IgA水平下降,差异均有统计学意义(Pa<0.05);与健康对照组比较,癫癎组患儿血清IgM水平亦明显下降(P<0.05)。与FS组及健康对照组比较,癫癎组患儿血CD4水平下降,差异有统计学意义(P<0.05);与健康对照组比较,癫癎组患儿血CD3水平亦明显下降。3组血清补体C3、C4水平、血CD8、CD4/CD8差异均无统计学意义(Pa>0.05)。结论癫癎患儿存在部分免疫功能低下及免疫功能紊乱。
Objective To study the immune status of children with epilepsy. Methods The levels of serum immunoglobulin and complement in children with epilepsy (epilepsy group), children with febrile seizure (FS) and healthy children (healthy control group) were determined by one-way agar diffusion method. The levels of serum immunoglobulin and complement were measured by direct immunofluorescence The blood T lymphocyte (CD) ratio was measured. Results Compared with FS group and healthy control group, serum IgG and IgA levels in epilepsy group were significantly lower than those in control group (P <0.05). Compared with healthy control group, serum IgM levels were also significantly higher in epileptic group Decreased (P <0.05). Compared with FS group and healthy control group, CD4 level in children with epilepsy group decreased significantly (P <0.05). Compared with healthy control group, serum CD3 level in children with epilepsy group also decreased significantly. There was no significant difference in serum C3, C4 levels, blood CD8, CD4 / CD8 between the three groups (Pa> 0.05). Conclusion There are some immunological dysfunction and immune dysfunction in children with epilepsy.