论文部分内容阅读
Pho P与Pho R组成的Pho PR是结核分枝杆菌重要的双组分调节系统。Pho P作为应答调节子调节基因的表达,这些基因参与细胞壁脂质合成,并对结核分枝杆菌毒力有重要调控作用。本文综述了Pho P的结构、性质以及相关的结核分枝杆菌疫苗研发情况,并提出了未来可能的研究趋势。
Pho PR with Pho P and Pho R is an important two-component regulator of M. tuberculosis. Pho P regulates the expression of genes as response regulators, which are involved in the lipid synthesis of cell walls and have an important regulatory effect on the virulence of M. tuberculosis. This review summarizes the structure and properties of Pho P and the related research and development of Mycobacterium tuberculosis vaccine and points out the possible future research trends.