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目的探讨云南省德宏傣族景颇族自治州艾滋病病毒(HIV)感染者基质细胞衍生因子(SDF-1)等位基因多态性与其疾病进程的关联性。方法应用病例对照研究设计,比较分析疾病长期不进展(LTNPs)和疾病典型进展(TPs)的HIV感染者SDF-1等位基因多态性频率。结果共有180例HIV感染者纳入研究,SDF-1等位基因野生纯合子(GG基因型)频率为53.9%,杂合子(GA基因型)频率为36.7%,突变纯合子(AA基因型)频率为9.4%。142例TPs者中,SDF-1等位基因野生纯合子(GG基因型)、杂合子(GA基因型)和突变纯合子(AA基因型)的频率分别为52.2%、40.8%和7.0%;38例LTNPs者中,SDF-1等位基因野生纯合子(GG基因型)、杂合子(GA基因型)和突变纯合子(AA基因型)的频率分别为61.5%、21.1%和18.4%。性别、年龄以及民族因素与SDF-1等位基因多态性分布无显著关联,但LTNPs者中突变纯合子(AA基因型)的频率高于TPs者,差异有统计学意义(χ2=4.54,P=0.033)。多因素logistic回归分析调整控制了性别、年龄和民族因素潜在的混杂作用后,这种关联性不再显著(OR=2.09;95%CI:0.60,7.22;P=0.246)。结论有必要加大对云南省德宏傣族景颇族自治州HIV感染者队列的观察和随访力度,以进一步明确HIV感染者的疾病进程与SDF-1等位基因多态性之间的关联性。
Objective To investigate the association of stromal cell-derived factor (SDF-1) alleles with the progression of the disease in HIV-infected Dehong Dai and Jingpo Autonomous Prefecture of Yunnan Province. Methods A case-control study was designed to compare the frequencies of SDF-1 alleles in HIV-infected individuals with long-term disease-free progression (LTNPs) and disease-typical progression (TPs). Results A total of 180 HIV-infected patients were enrolled in this study. The frequencies of wild-type homozygotes (GG genotypes) of SDF-1 alleles were 53.9%, heterozygous (GA genotypes) frequencies were 36.7%, frequency of homozygous homozygotes (AA genotypes) 9.4%. Among 142 TPs, the frequency of wild type homozygote (GG genotype), heterozygote (GA genotype) and mutation homozygous (AA genotype) of SDF-1 allele were 52.2%, 40.8% and 7.0% respectively. The frequency of wild-type homozygotes (GG genotypes), heterozygotes (GA genotypes) and homozygous AA (AA genotypes) of SDF-1 alleles were 61.5%, 21.1% and 18.4% respectively in 38 cases of LTNPs. Gender, age and ethnicity were not significantly associated with the distribution of SDF-1 alleles, but the frequencies of AA homozygotes in LTNPs were higher than those in TPs (χ2 = 4.54, P = 0.033). Multivariate logistic regression analysis adjusted for potential mixed effects of gender, age, and ethnicity with no significant association (OR = 2.09; 95% CI: 0.60, 7.22; P = 0.246). Conclusion It is necessary to increase the observation and follow-up of cohorts of HIV-infected patients in Dehong Dai and Jingpo Autonomous Prefecture of Yunnan Province to further clarify the association between the disease progression of the HIV-infected persons and the SDF-1 allelic polymorphism.