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目的对绣球防风Leucas ciliata的化学成分进行研究。方法利用正相硅胶、RP-18柱色谱、葡聚糖凝胶SephadexLH-20等方法进行分离纯化,根据波谱数据鉴定化合物的结构。结果从绣球防风乙醇提取物中分离得到12个化合物,通过光谱数据分析,分别鉴定为苜蓿素(1)、crisilineol(2)、胡萝卜苷(3)、stigmast-5-ene-11-ol-3-O-β-glucoside(4)、5,7-dimethoxy-2-methyl-4-chromanone(5)、3′,5′,5,7-tetramethoxy-4′-O-β-glucoside flavone(6)、5-hydroxy-3′,4′-dimethoxy-7-O-β-glucoside flavone(7)、acteoside(8)、3,4-dihydroxy-β-phenylethoxy-O-α-L-arabinopyranosyl-(1′′′′→2″)-α-L-rhamnopyranosyl-(1′′′→3″)-4″-O-caffeoyl-β-D-glucopyranoside(9)、3-hydroxy-4-methoxy-β-phenylethoxy-O-α-L-arabino-pyranosyl-(1′′′′→6″)-α-L-rhamnopyranosyl-(1′″→3″)-4″-O-caffeoyl-β-D-glucopyranoside(10)、leucasin A(11A)和leucasin B(11B)。结论化合物11A和11B为一对差向异构体,并且为新化合物,其余10个化合物均为首次从该属植物中分离得到。
Aim To study the chemical constituents of Leucas ciliata in hydrangea. Methods The compounds were isolated and purified by normal phase silica gel, RP-18 column chromatography and Sephadex LH-20 dextran gel electrophoresis. The structures of the compounds were identified by spectral data. Results Twelve compounds were isolated from the ethanol extract of Hydrangea gossypii and identified as alfalfa (1), crisilineol (2), daucoster (3), stigmast-5-ene-11-ol-3 O-β-glucoside (4), 5,7-dimethoxy-2-methyl-4-chromanone (5), 3 ’, 5’, 5,7-tetramethoxy-4’-O- ), 5-hydroxy-3 ’, 4’-dimethoxy-7-O-β-glucoside flavone (7), acteoside (8), 3,4-dihydroxy-β-phenylethoxy-O-α-L-arabinopyranosyl- -O-caffeoyl-β-D-glucopyranoside (9), 3-hydroxy-4-methoxy- β -phenylethoxy-O-α-L-arabino-pyranosyl- (1 ’“→ 6”) - α-L- rhamnopyranosyl- (1’ “→ 3”) - 4 "-O-caffeoyl-β-D (11) and leucasin B (11B) .Conclusion Compounds 11A and 11B are a pair of epimers and are new compounds, and the remaining 10 compounds are all isolated from this genus for the first time get.