目的：观察大黄合剂和乳果糖联用灌肠治疗急性肾功能衰竭（ＡＲＦ）患者的疗效。方法：４６例患者随机分为２组。治疗组采用大黄合剂、乳果糖每隔３ｈ交替保留灌肠。对照组仅采用大黄合剂保留灌肠。结果：治疗组显效１５例，有效７例，总有效率９１６％；对照组显效１０例，有效８例，总有效率８１８％，治疗组大便导泻量、血尿素氮（ＢＵＮ）、肌酐（Ｃｒ），血压和尿量等各项指标的变化均明显优于对照组（Ｐ＜０００１）。结论：大黄合剂和乳果糖灌肠治疗ＡＲＦ疗效确切 Objective: To observe the curative effect of rhubarb mixture and lactulose combined enema on patients with acute renal failure (ARF). Methods: 46 patients were randomly divided into two groups. The treatment group with rhubarb mixture, lactulose alternate enema every 3h. Control group only use rhubarb mixture retention enema. Results: In the treatment group, 15 cases were markedly effective and 7 cases were effective. The total effective rate was 91.6%. In the control group, 10 cases were markedly effective and 8 cases were effective. The total effective rate was 81.8%. The amount of stool in the treatment group, blood urea nitrogen (BUN) ), Creatinine (Cr), blood pressure and urine volume were significantly higher than the control group (P <0001). Conclusion: Rhubarb mixture and lactulose enema treatment of ARF exact effect