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目的应用人重组白细胞介素Ⅱ（ｒｈＩＬ２）配合常规药物治疗兔单纯疱疹性角膜炎（ＨＳＫ）预防复发。方法给兔接种ＨＳＶ前１０天应用ｒｈＩＬ２提高免疫功能治疗，待形成ＨＳＫ后配合常规药物治疗，同时设对照组。应用ＰＣＲ技术检测观察兔感染ＨＳＶ１体内动态变化，依据ＨＳＫ诊断标准观察其疗效。结果实验组与对照组相比有延长潜伏感染期、发病轻、病程短、恢复快，ＨＳＶ在三叉神经节潜伏率低。结论应用ｒｈＩＬ２能治疗兔ＨＳＫ和预防复发，无不良反应。
Objective To prevent the recurrence of herpes simplex keratitis (HSK) treated with recombinant human interleukin Ⅱ (rhIL2) and conventional drugs. Methods 10 days before HSV vaccination with rhIL 2 to improve immune function, to be formed after HSK with conventional drug treatment, while the control group. Application of PCR technology to detect rabbit in vivo HSV 1 dynamic changes, according to HSK diagnostic criteria to observe its efficacy. Results Compared with the control group, the experimental group had prolonged latent infection period, mild onset of disease, short course of disease, rapid recovery and low latent rate of HSV in the trigeminal ganglion. Conclusion rhIL 2 can treat rabbit HSK and prevent recurrence, no adverse reactions.