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目的:观察替比夫定所致周围神经和肌肉病变的临床观察,并分析其与合并用药等因素的相关性。方法:对2007年8月～2008年10月我院应用替比夫定治疗慢性乙肝出现周围神经和肌病的患者进行观察,对合并用药、用法用量、实验室检查和患者病情等情况进行综合分析。结果:8例患者均为男性,年龄在25～50之间,其中2例患者合并应用干扰素,8例患者在出现肌肉病变的同时伴有CK水平的升高,其中有7例出现了周围神经系统异常,其中1例出现横纹肌溶解。结论:替比夫定可能会引起周围神经及肌肉病变,需引起医务人员和患者的广泛关注。
Objective: To observe the clinical observation of telbivudine-induced peripheral nerve and muscle lesions, and analyze its correlation with the combination of medication and other factors. Methods: From August 2007 to October 2008, patients in our hospital were treated with telbivudine for the treatment of peripheral nerves and myopathy in patients with chronic hepatitis B. The combination of medication, dosage, laboratory tests and patient’s condition were observed analysis. Results: All 8 patients were male, ranging in age from 25 to 50, of whom 2 patients combined with interferon and 8 patients had muscular lesions accompanied by increased CK levels, of which 7 cases appeared around Nervous system abnormalities, including rhabdomyolysis in 1 case. Conclusion: Telbivudine may cause peripheral nerve and muscle lesions, requiring medical personnel and patients to pay close attention to.