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目的:分析宫颈分泌物胎儿纤维连接蛋白(fFN)、胰岛素样生长因子结合蛋白-1(IGFBP-1)和β-HCG3项联合检测在预测早产中的临床应用。方法:选择先兆早产孕妇200例,随机分为4组各50例,应用免疫测定法定性检测宫颈阴道分泌物中fFN、IGFBP-1和β-HCG。A组行fFN检测,B组行IGFBP-1检测,C组行β-HCG的检测,D组3者联合检测,通过分娩结局对照,计算4种方法的准确性、阳性预测值和阴性预测值并相互比较。结果:A组准确性84.00%,阳性预测值66.66%,阴性预测值91.42%。B组准确性80.00%,阳性预测值63.15%,阴性预测值90.32%。C组准确性86.00%,阳性预测值62.50%,阴性预测值97.06%;D组准确性96.00%,阳性预测值92.86%,阴性预测值100.00%。4种检测方法比较上述指标差异有统计学意义。结论:联合筛查可作为预测早产的有效指标,提高了准确性、阳性预测值和阴性预测值。
Objective: To analyze the clinical application of combined detection of fetal fibronectin (fFN), insulin-like growth factor binding protein-1 (IGFBP-1) and β-HCG3 in the prediction of preterm labor. Methods: 200 pregnant women with threatened preterm labor were selected and randomly divided into 4 groups of 50 cases. The fFN, IGFBP-1 and β-HCG in cervical vaginal secretions were detected by immunoassay. A group of line fFN test, group B line IGFBP-1 test, group C line β-HCG test, D group 3 combined detection, delivery outcome through control, the four methods of accuracy, positive predictive value and negative predictive value Compare with each other. Results: The accuracy of group A was 84.00%, the positive predictive value was 66.66%, the negative predictive value was 91.42%. The accuracy of group B was 80.00%, the positive predictive value was 63.15% and the negative predictive value was 90.32%. The accuracy of group C was 86.00%, the positive predictive value was 62.50%, the negative predictive value was 97.06%. The accuracy of group D was 96.00%, the positive predictive value was 92.86% and the negative predictive value was 100.00%. Four kinds of test methods to compare the above indicators were statistically significant. Conclusion: Combined screening can be used as an effective indicator to predict preterm birth, and improve the accuracy, positive predictive value and negative predictive value.