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目的:探讨磷酸肌酸钠(CP)和1,6-二磷酸果糖(FDP)治疗小儿心肌损害的疗效。方法:将58例心肌损害患儿随机分为治疗组32例和对照组26例,两组患儿均在治疗原发病基础上,治疗组给予CP(唯嘉能)<1岁者0.5 g/d,≥1岁者1 g/d,对照组予FDP 250 mg.kg-1.d-1,静脉滴注,10天为1疗程。两组均于治疗1疗程后复查心肌酶谱、血肌钙蛋白I及心电图。结果:治疗组总有效率为96.88%,对照组为84.62%,两组疗效比较差异有统计学意义(P<0.05)。结论:CP对各种原因所致心肌损害的治疗均优于FDP,可作为有心肌损害患儿的首选。
Objective: To investigate the efficacy of sodium creatine phosphate (CP) and fructose-1,6-diphosphate (FDP) in the treatment of myocardial damage in children. Methods: Fifty-eight children with myocardial damage were randomly divided into treatment group (32 cases) and control group (26 cases). Both groups were treated on the basis of primary disease. The treatment group was given 0.5 g / d, ≥ 1 year old 1 g / d, control group to FDP 250 mg.kg-1.d-1, intravenous drip, 10 days for a course of treatment. The two groups were reviewed after a course of treatment of myocardial enzymes, cardiac troponin I and ECG. Results: The total effective rate was 96.88% in the treatment group and 84.62% in the control group, the difference between the two groups was statistically significant (P <0.05). Conclusion: CP is superior to FDP in the treatment of myocardial damage caused by various reasons, which may be the first choice for children with myocardial damage.