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目的探讨芹菜对雄性小鼠生殖能力及胎鼠生长发育的影响。方法160只成年健康SPF级昆明种雄性小鼠按体质量随机分为7d和56d两个时间组,各时间组随机分为对照组、低剂量组、中剂量组、高剂量组,每天定时给各剂量组小鼠以不同浓度的芹菜汁0.3ml灌胃,对照组0.3ml生理盐水灌胃,灌胃结束后与同种同龄的健康雌性小鼠按雄雌1∶1合笼;次日起每日阴道涂片,以查到阴栓为孕0d(合笼7d未见阴栓者,以合笼第4天为孕0d),并分笼饲养,分别在孕18d剖腹取胎,记录各组孕鼠受孕及子宫仔鼠着床情况,同时测定胎鼠身长及体质量。结果各剂量组与对照组比较雌鼠受孕率、着床数、胎鼠身长、体质量差异均无统计学意义。结论芹菜对胎鼠生长发育无明显影响,对雄鼠生育力的影响不能排除。
Objective To investigate the effects of celery on reproductive ability and fetal rat growth and development in male mice. Methods Male adult Kunming SPF Kunming mice were randomly divided into two groups according to the body weight at 7 days and 56 days. The rats in each time group were randomly divided into control group, low dose group, middle dose group and high dose group, Mice in each dose group with different concentrations of celery juice 0.3ml gavage, the control group of 0.3ml saline gavage, gavage and healthy female mice of the same age by male and female 1: 1 cage; the next day Daily vaginal smear to find the vaginal suppository for 0d (cage 7d no vaginal suppository to cage the fourth day of pregnancy 0d), and sub-cage feeding, respectively, in the first 18d caesarean section fetus, record each Pregnant group of pregnant rats and uterus offspring implantation, fetal body length and body weight determination. Results Compared with control group, there were no significant differences in pregnancy rate, implantation number, fetal body length and body weight among all dose groups and control groups. Conclusion Celery has no significant effect on the growth and development of fetal rats, but the effect on male fertility can not be ruled out.