论文部分内容阅读
目的 探讨碳酸锂联合奥氮平治疗双相Ⅰ型障碍躁狂发作的临床疗效及安全性.方法 将80例双相Ⅰ型障碍躁狂发作患者按随机数字表法分为两组,每组40例.两组均予以碳酸锂治疗,研究组在此基础上联合奥氮平治疗,治疗前后采用杨氏躁狂量表、倍克·拉范森躁狂量表、临床总体印象疾病严重程度量表-双相障碍及副反应量表评定临床疗效及安全性. 结果 治疗前两组各量表总分比较差异无统计学意义(P>0.05);治疗后两组杨氏躁狂量表、倍克·拉范森躁狂量表、临床总体印象疾病严重程度量表-双相障碍总分均较治疗前显著降低(P<0.01),研究组显著低于对照组(P<0.01);治疗8周末研究组总有效率为90.0%,对照组为72.5%,研究组显著高于对照组(P<0.05).治疗后研究组副反应量表总分显著低于对照组(P0.05);after treatment the YMRS, BRMS and CGI-S-BP scores of both groups lowered more significantly (P<0.01) and those were significantly lower in research than in control group (P<0.01);at the end of the 8th week the total effective rate was respectively 90.0% in research and 72.5% in control group and the former significantly higher than the latter (P<0.05).After treatment the total score of the TESS was significantly lower in research than in control group (P<0.05).Conclusion Lithium carbonate combined with olanzapine has an evident effect and higher safety compared with single lithium carbonate in the treatment of manic episode of bipolar I disorder.