去甲斑蝥素为斑蝥素的衍生物,与斑蝥素有类似的抗肿瘤作用,但其毒性明显低于斑蝥素。研究表明,斑蝥素及其衍生物临床应用主要有两方面:一是抗病毒,抑制病毒的复制,可以内服治疗乙型肝炎和外涂治疗尖锐湿疣;二是抗肿瘤,对多种实体瘤具有生长抑制作用,如肝癌、卵巢癌和乳腺癌等。文章重点综述其抗肿瘤机制,即抑制蛋白磷酸酶,影响细胞正常的生理代谢功能和增强p53功能,诱导细胞凋亡,从而起到抑癌、抗癌的作用。 Norcantharidin is a derivative of cantharidin, and cantharidin has a similar anti-tumor effect, but its toxicity was significantly lower than cantharidin. Studies have shown that the clinical application of cantharidin and its derivatives mainly in two ways: First, the anti-virus, inhibit viral replication, can be taken orally to treat hepatitis B and topical treatment of genital warts; Second, anti-tumor, for a variety of solid tumors have Growth inhibition, such as liver cancer, ovarian cancer and breast cancer. The article focuses on its anti-tumor mechanisms, namely inhibition of protein phosphatase, affect the normal physiological function of cells metabolism and enhance the function of p53, induce apoptosis, which play a role in tumor suppressor and anti-cancer.