基质金属蛋白酶(MMP)是一组分解细胞外基质的钙锌离子依赖型蛋白酶的总称。牙本质粘接剂酸性环境可以激活MMP酶原,进而分解暴露的胶原纤维,破坏粘接界面而导致粘接的失败。抑制MMP可有效增加粘接耐久性。本文就MMP在粘接过程中的激活和对粘接耐久性的影响以及MMP抑制剂的研究进展作一综述。 Matrix metalloproteinases (MMPs) are a group of calcium and zinc-dependent proteases that break down the extracellular matrix. Dentin adhesive acidic environment can activate MMP proenzyme, and then break down the exposed collagen fibers, damage the bonding interface and lead to the failure of bonding. Inhibition of MMPs can effectively increase bonding durability. In this paper, the activation of MMP in the bonding process and the impact on the bonding durability and the progress of MMP inhibitors are reviewed.