目前就细胞凋亡启动与执行的分子作用机制已作了大量的研究 ,其中由死亡配体 /死亡受体激活半胱天冬(氨酸 )蛋白酶 (caspase)而完成细胞凋亡的通路较为清晰 ,caspase还可受其他的刺激而直接被激活从而执行凋亡 ,提示不同的作用因素可殊途同归而使细胞凋亡。弄清楚细胞凋亡通路特别是其下游的分子作用机制 ,可通过调控凋亡启动与执行分子 ,来控制各种原因所致的不可逆性细胞死亡的发生 ,从而为疾病的治疗提供了新的思路、方法与希望 At present, a great deal of research has been done on the molecular mechanism of apoptosis initiation and execution, in which the pathways of completing apoptosis are activated by the death ligand / death receptor activating caspase , caspase can also be directly activated by other stimuli in order to perform apoptosis, suggesting that different factors can be the same path to apoptosis. To clarify the molecular mechanism of apoptosis, especially downstream, can control the occurrence of irreversible cell death caused by various causes by regulating the promoter and the promoter of apoptosis, thus providing a new idea for the treatment of the disease , Methods and hope