论文部分内容阅读
目的探讨子宫内膜异位症(内异症)伴不孕患者血清和腹腔液中瘦素水平的变化,以期阐明其在内异症伴不孕发病机制的作用。方法采用放射免疫分析法(RIA)测定30例内异症伴不孕症患者和25例对照组患者血清和腹腔液的瘦素的水平并进行相关性分析。结果瘦素在内异症伴不孕症患者和对照组血清中的水平分别为(2·96±1·33)μg/L、(2·57±0·98)μg/L,两组比较,差异无统计学意义(P>0·05);在腹腔液中分别为(4·58±9·36)μg/L、(2·31±8·01)μg/L,差异有统计学意义(P<0·01)。结论内异症伴不孕患者腹腔液中瘦素水平显著增加,瘦素可能在内异症伴不孕的发病机制中起重要作用。
Objective To investigate the changes of serum and peritoneal levels of leptin in patients with endometriosis (endometriosis) and infertility, in order to clarify its role in the pathogenesis of infertility with endometriosis. Methods Serum and peritoneal levels of leptin in 30 patients with endometriosis and 25 controls were determined by radioimmunoassay (RIA) and their correlations were analyzed. Results The levels of leptin in the serum of patients with endometriosis and infertility were (2.96 ± 1.33) μg / L and (2.57 ± 0.98) μg / L, respectively , Respectively. There was no significant difference between the two groups (P> 0.05) and in peritoneal fluid (4.58 ± 9.36 μg / L and (2.31 ± 8.01) μg / L, respectively) Significance (P <0 · 01). Conclusions Leptin levels in peritoneal fluid of patients with endometriosis and infertility are significantly increased. Leptin may play an important role in the pathogenesis of endometriosis and infertility.