夜间酸突破现象在各类人群中都有着极高的发生率,其发生机制复杂,参与因素较多,与幽门螺杆菌感染的情况及人种的不同等诸多因素均有重要的相关性。NAB的存在与消化性溃疡出血、反流性食管炎、Barrett食管等酸相关性疾病的症状及疗效密切相关。本文将对NAB发病机理、其与酸相关性疾病的关系及治疗等方面做一综述。 Night acid breakthrough in all types of people have a very high incidence, the mechanism of its occurrence is complex, more involved factors, and Helicobacter pylori infection and ethnic differences and many other factors have important relevance. The presence of NAB is closely related to the symptoms and efficacy of acid-related diseases such as peptic ulcer bleeding, reflux esophagitis, and Barrett’s esophagus. This article will review the pathogenesis of NAB, its relationship with acid-related diseases and its treatment.