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目的探讨葫芦巴、鹰嘴豆、石榴皮水提物对二肽基肽酶Ⅳ(DPP-4)体外活性的影响。方法采用DPP-4体外抑制模型,对新疆具有降糖作用的葫芦巴、鹰嘴豆、石榴皮3种植物水提取物进行筛选,选择抑二肽素A(IIe-pro-IIe)作为阳性对照药物,比较3种水提物的IC50差异。结果 IIe-pro-IIe的IC50为(0.01±0.01)mg/mL,葫芦巴水提物IC50为(0.03±0.01)mg/mL,石榴皮水提物IC50为(0.19±0.13)mg/mL,鹰嘴豆水提物IC50为(0.09±0.07)mg/mL。结论葫芦巴、石榴皮、鹰嘴豆的水提取物对DPP-4有一定程度的抑制作用。
Objective To investigate the effects of aqueous extract of fenugreek, chickpea and pomegranate peel on the activity of dipeptidyl peptidase Ⅳ (DPP-4) in vitro. Methods DPP-4 in vitro inhibition model was used to screen the water extract of three plants of fenugreek, chickpea and pomegranate that had hypoglycemic effect in Xinjiang, and choose IIe-pro-IIe as positive control Drugs, IC50 differences between the three water extracts were compared. Results The IC50 of IIe-pro-IIe was (0.01 ± 0.01) mg / mL and that of Fenugreek water extract was (0.03 ± 0.01) mg / mL. The IC50 of water extract of pomegranate rind was (0.19 ± 0.13) mg / The IC50 of chickpea water extract was (0.09 ± 0.07) mg / mL. Conclusion The water extract of fenugreek, pomegranate peel and chickpea had some inhibitory effect on DPP-4.