肿瘤坏死因子(TNF)系免疫系统对各种感染及肿瘤动因应答过程中释放的一种重要介质,可激活多形核白细胞,增强吞噬细胞活性,刺激前列腺素E和胶原酶的生成,以及促进纤维母细胞的增殖,并具有破骨细胞激活因子的活性。除内毒素外,病毒颗粒,肿瘤细胞,以及能致有丝分裂的物质,均可激发其释放。作者对23例(3～8岁)分泌性中耳炎患儿,经鼓膜切开术抽液,将27份标本(21份为粘液 Tumor necrosis factor (TNF) is an important mediator of immune system response to various infections and tumor motivations. It activates polymorphonuclear leukocytes, enhances phagocyte activity, stimulates prostaglandin E and collagenase production, and promotes Proliferation of fibroblasts, and osteoclast activator activity. In addition to endotoxins, viral particles, tumor cells, and mitogenic substances can all stimulate their release. The authors of 23 cases (3 to 8 years old) children with otitis media with effusion by eardrum drainage, 27 specimens (21 were mucus