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支气管哮喘的发病涉及遗传、免疫和环境等因素。国内外已有报道，支气管哮喘与ＭＨＣ基因有关。低分子量多肽（ｌｏｗｍｏｌｅｃｕｌａｒ ｗｅｉｇｈｔ ｐｅｐｔｉｄｅ，ＬＭＰ）作为加工抗原蛋白酶体的亚基，其基因定位于人第６对染色体短臂上的ＭＨＣ区域，并与ＨＬＡ－Ｉ、
The incidence of bronchial asthma involves genetic, immune and environmental factors. It has been reported at home and abroad, bronchial asthma and MHC genes. Lowmolecular weight peptide (LMP), as a subunit of processing antigen proteasome, locates in the MHC region on the short arm of human chromosome 6 and interacts with HLA-I,